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NF-B, the master transcriptional regulator of pro-inflammatory gene expression, is activated downstream of TNF receptor and IL-1 receptor signaling

This coordinated action results in stronger, more resilient repaired tissue with reduced scar formation

Although the number of injections that would be administered would very much depend on the extent of the nerve damage, they are normally administered over several weeks or months

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In peer-reviewed animal work the concrete numbers are oral doses of roughly 1.442.88 mg/kg given daily to APP/PS1 Alzheimer-model mice over about three months [3] , and low-mg/kg dosing that reversed scopolamine-induced deficits in rodents [1]